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MERRF is a chronic situation, which is slowly progressive. As defined above, completely different people become symptomatic with totally different phenotypes and at completely different ages, even throughout the identical household. Hence, the exact prognosis is troublesome to ascertain, but normally, it’s poor. Electroencephalogram may reveal a sluggish background activity with generalized epileptiform discharges, which can precipitate with photic stimulation. These EEG options can also be seen in MELAS and different progressive myoclonic epilepsies.Electromyography and nerve conduction research (EMG/NCS) might reveal small polyphasic motor items with early recruitment consistent with a myopathic process.